Tretinoin/benzoyl peroxide (On the skin)
Benzoyl Peroxide (BEN-zoe-il per-OX-ide), Tretinoin (TRET-i-noin)
TwyneoThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:
This medicine is not right for everyone. Do not use it if you had an allergic reaction to tretinoin or benzoyl peroxide.
How to Use This Medicine:
- Your doctor will tell you how much medicine to use. Do not use more than directed.
- Use this medicine only on your skin. Do not get it in your eyes, nose, corners of your nose, lips, mouth, or vagina. Do not use on skin areas that have cuts, scrapes, or sunburn. If it does get on these areas, rinse it off right away.
- Wash your hands with soap and water before and after you use this medicine.
- Apply a thin layer of the medicine to the affected area. Rub it in gently.
- Do not apply this medicine in your hair or on colored fabric. It may bleach your hair or colored fabric.
- Your doctor may tell you to use a moisturizer to treat skin irritation.
- Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
- Missed dose: Apply a dose as soon as you can. If it is almost time for your next dose, wait until then and apply a regular dose. Do not apply extra medicine to make up for a missed dose.
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Do not freeze.
- Throw away any unused medicine 12 weeks after the date you receive it or 30 days after first opening, whichever is sooner.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Warnings While Using This Medicine:
- Tell your doctor if you are pregnant or breastfeeding, or if you have other skin problems (including eczema, cuts, or sunburn).
- This medicine may cause serious skin reactions.
- Do not use this medicine to treat a skin problem your doctor has not examined.
- This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.
- Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Pain, burning, changes in color, dryness, itching, peeling, redness, scaling, stinging, or swelling of the skin where the medicine is applied
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Last Updated: 8/5/2022
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