Cariprazine (By mouth)
Treats schizophrenia and bipolar disorder (including mania and depression).
Vraylar, Vraylar Titration KitThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:
This medicine is not right for everyone. Do not use it if you had an allergic reaction to cariprazine.
How to Use This Medicine:
- Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
- Some side effects may not happen right away and can start a few weeks after you start using this medicine or if your dose increases. Do not change your dose or stop using your medicine without first checking with your doctor.
- This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
- Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Some medicines can affect how cariprazine works. Tell your doctor if you are using carbamazepine, itraconazole, ketoconazole, or rifampin.
Warnings While Using This Medicine:
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, diabetes, high cholesterol, trouble swallowing, or a history of seizures. Tell your doctor if you have heart or blood vessel problems, including low blood pressure, heart failure, heart rhythm problems, or a history of heart attack or stroke.
- This medicine may cause the following problems:
- Neuroleptic malignant syndrome, which can be life-threatening
- Tardive dyskinesia (trouble controlling movements), which may become permanent
- High blood sugar level
- Increased risk of seizures
- This medicine may make you dizzy, drowsy, or lightheaded, especially when you first use it or when the dose is changed. It may also cause trouble with controlling body movements, which may lead to falls, fractures, or other injuries. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Standing up slowly from a sitting or lying position can lessen the chance of getting dizzy.
- This medicine may cause you to become overheated. Drink plenty of water during hot weather or when exercising.
- This medicine lowers the number of white blood cells. This weakens your immune system, so you may get infections more easily. Wash your hands often. Avoid people who are sick.
- For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or anyone in your family has a history of bipolar disorder or suicide attempts.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Fever, chills, cough, sore throat, body aches
- Increased hunger or thirst, frequent urination
- Jerky muscle movements that you cannot control (often in your face, tongue, or jaw), problems with balance or walking, restlessness
- Lightheadedness, dizziness, drowsiness
- Seizures, tremors
- Sweating, confusion, uneven heartbeat, muscle stiffness
- Unusual changes in behavior, thoughts or attempts of killing oneself
If you notice these less serious side effects, talk with your doctor:
- Constipation, diarrhea, nausea, vomiting, stomach pain
- Headache, trouble sleeping
- Weight gain
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Last Updated: 6/2/2022
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