Fluorouracil (On the skin)
Treats actinic or solar keratoses and basal cell carcinoma (skin cancer).
Carac, Efudex, Fluoroplex, TolakThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:
This medicine is not right for everyone. Do not use it if you had an allergic reaction to fluorouracil, if you are pregnant, or if you have dihydropyrimidine dehydrogenase (DPD) enzyme deficiency.
How to Use This Medicine:
- Your doctor will tell you how much medicine to use. Do not use more than directed.
- This medicine is for use only on your skin. Do not get any of this medicine near or around your eyes, nose, or mouth. Rinse it off right away if it does get on these areas.
- Wash your hands with soap and water before and after you use this medicine.
- Apply a thin layer of the medicine to the affected area. Rub it in gently.
- You may use a glove, nonmetal applicator, or your fingers to apply this medicine.
- Do not cover the treated area with a bandage unless directed by your doctor.
- Missed dose: Apply a dose as soon as you can. If it is almost time for your next dose, wait until then and apply a regular dose. Do not apply extra medicine to make up for a missed dose.
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Keep this medicine away from pets. Do not allow pets to contact the skin where the medicine is applied. Throw away or clean any cloth or applicator that may still have some of this medicine. Do not leave any medicine on your hands, clothing, carpet, or furniture.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Do not put cosmetics or skin care products on the treated skin.
Warnings While Using This Medicine:
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
- Tell your doctor if you are breastfeeding or if you have other skin problems.
- This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Diarrhea that contains blood, stomach pain, vomiting
- Fever, chills, cough, sore throat, body aches
- Swelling, blistering, redness, or peeling of the skin
- Unusual bleeding, bruising, or weakness
If you notice these less serious side effects, talk with your doctor:
- Eye burning, itching, stinging, or watering
- Hair loss
- Sores or white patches on your lips, mouth, or throat
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Last Updated: 6/2/2022
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