Treatments & Care at NCH

Health Library

     
Print-Friendly
Bookmarks

Hereditary amyloidosis

Amyloidosis - hereditary; Familial amyloidosis

Hereditary amyloidosis is a condition in which abnormal protein deposits (called amyloid) form in almost every tissue in the body. Harmful deposits most often form in the heart, kidneys, and nervous system. These protein deposits damage the tissues and interfere with how organs work.

Causes

Hereditary amyloidosis is passed down from parents to their children (inherited). Genes may also play a role in primary amyloidosis.

Other types of amyloidosis are not inherited. They include:

  • Senile systemic: seen in people older than 70
  • Spontaneous: occurs without a known cause
  • Secondary: results from diseases such as cancer of the blood cells (myeloma)

Specific conditions include:

Treatment

Treatment to improve the function of damaged organs will help relieve some symptoms of hereditary amyloidosis. A liver transplant may be helpful to reduce the creation of harmful amyloid proteins. Talk to your health care provider about treatments.

References

Gertz MA. Amyloidosis. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 179.

Lachmann HJ, Sharpley FA. Amyloidosis. In: Firestein GS, Budd RC, Gabriel SE, Koretzky GA, McInnes IB, O'Dell JR, eds. Firestein & Kelley's Textbook of Rheumatology. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 123.

BACK TO TOP

    • Amyloidosis of the fingers

      Amyloidosis of the finge...

      illustration

      • Amyloidosis of the fingers

        Amyloidosis of the finge...

        illustration

       

      Review Date: 11/5/2021

      Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

      The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., a business unit of Ebix, Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
      © 1997- adam.comAll rights reserved.

       
       
       

       

       

      A.D.A.M. content is best viewed in IE9 or above, Firefox and Google Chrome browser.